Guru Ram Das was born in Chuna Mandi Lahore, Punjab on 9 October 1534 to a Sodhi family of the Khatri clan. His father was Hari Das and his mother Anup Devi. Known as Jetha meaning the first born, he was a handsome young man. When he grew up he could always be found in the company of religious men.One day Jetha came across a party of Sikhs who were on their way to Goindwal to pay homage to Guru Amar Das. Jetha decided to join them and also travel to Goindwal. Upon their arrival and meeting, Guru Amar Das at once noticed the young Jetha with his pleasant manner and sense of devotion. While his fellow travelers returned to Lahore, Jetha decided to stay and become a disciple of Guru Amar Das. His wife was Bibi Bhani, the younger daughter of Guru Amar Das. They had three sons: Prithi Chand, Mahadev and Guru Arjun Dev Ji.His father-in-law, Guru Amar Das, was third of the Ten Gurus. Amar Das installed Ram Das as the fourth guru on 1st September 1574.
In Amritsar, he designed the gurdwara (ਗੁਰਦੁਆਰਾ) Harmandir Sahib (ਹਰਿਮੰਦਰ ਸਾਹਿਬ), which translates as “The Abode of God” also known as the Golden Temple.
Before His death, He passed the light of Guruship to His Son Guru Arjun Dev. Guru Ram Das died on 1 September 1581, in the city of Amritsar, Punjab.